The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers.
Identifieur interne : 000549 ( Main/Exploration ); précédent : 000548; suivant : 000550The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers.
Auteurs : E. D'Hondt [États-Unis] ; A. Eisbruch ; J A ShipSource :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 0275-1879 ]
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Dose de rayonnement (MeSH), Débit sécrétoire (effets des radiations), Femelle (MeSH), Glande parotide (métabolisme), Humains (MeSH), Irradiation crânienne (effets indésirables), Maladies de la glande parotide (physiopathologie), Maladies de la glande parotide (étiologie), Maladies de la glande salivaire (physiopathologie), Maladies de la glande salivaire (étiologie), Mâle (MeSH), Relation dose-effet des rayonnements (MeSH), Salivation (effets des radiations), Soins dentaires pour malades chroniques (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Tumeurs de la tête et du cou (radiothérapie).
- MESH :
- effets des radiations : Débit sécrétoire, Salivation.
- effets indésirables : Irradiation crânienne.
- métabolisme : Glande parotide.
- physiopathologie : Maladies de la glande parotide, Maladies de la glande salivaire.
- radiothérapie : Tumeurs de la tête et du cou.
- étiologie : Maladies de la glande parotide, Maladies de la glande salivaire.
- Adulte, Adulte d'âge moyen, Dose de rayonnement, Femelle, Humains, Mâle, Relation dose-effet des rayonnements, Soins dentaires pour malades chroniques, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Cranial Irradiation (adverse effects), Dental Care for Chronically Ill (MeSH), Dose-Response Relationship, Radiation (MeSH), Female (MeSH), Head and Neck Neoplasms (radiotherapy), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Parotid Diseases (etiology), Parotid Diseases (physiopathology), Parotid Gland (metabolism), Radiation Dosage (MeSH), Salivary Gland Diseases (etiology), Salivary Gland Diseases (physiopathology), Salivation (radiation effects), Secretory Rate (radiation effects).
- MESH :
- adverse effects : Cranial Irradiation.
- etiology : Parotid Diseases, Salivary Gland Diseases.
- metabolism : Parotid Gland.
- physiopathology : Parotid Diseases, Salivary Gland Diseases.
- radiation effects : Salivation, Secretory Rate.
- radiotherapy : Head and Neck Neoplasms.
- Adult, Aged, Aged, 80 and over, Dental Care for Chronically Ill, Dose-Response Relationship, Radiation, Female, Humans, Male, Middle Aged, Radiation Dosage.
Abstract
Radiotherapy (RT) used for head and neck cancers causes permanent salivary gland dysfunction (SGD). Previous short-term studies have demonstrated that pre-RT salivary flow rates and the amount of radiation exposure to parotid glands influence the amount of RT-induced SGD. The purpose of this study was to determine which variables are related to the development of long-term post-RT SGD. Parotid flow rates (PFR) were assessed prior to and 1 year after completion of RT in spared parotid glands from 34 patients from 2 parotid-sparing protocols. The results reveal that spared PFR were not significantly higher 1 year post-RT in patients who had high pre-RT PFR, when compared with patients with low pre-RT PFR. However, patients who received higher doses of RT to spared parotid glands had lower PFR 1 year post-RT, compared with patients who had received lower doses of RT. These one-year findings suggest that high pre-RT PFR do not provide protection against RT-induced SGD. Conversely, reduced RT dosages to contralateral parotid glands are protective of PFR after completion of RT.
DOI: 10.1111/j.1754-4505.1998.tb00913.x
PubMed: 9680919
Affiliations:
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D'Hondt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Medicine, Pathology, Surgery, University of Michigan School of Dentistry, Ann Arbor 48109-1078, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Medicine, Pathology, Surgery, University of Michigan School of Dentistry, Ann Arbor 48109-1078</wicri:regionArea><wicri:noRegion>Ann Arbor 48109-1078</wicri:noRegion></affiliation></author><author><name sortKey="Eisbruch, A" sort="Eisbruch, A" uniqKey="Eisbruch A" first="A" last="Eisbruch">A. 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Previous short-term studies have demonstrated that pre-RT salivary flow rates and the amount of radiation exposure to parotid glands influence the amount of RT-induced SGD. The purpose of this study was to determine which variables are related to the development of long-term post-RT SGD. Parotid flow rates (PFR) were assessed prior to and 1 year after completion of RT in spared parotid glands from 34 patients from 2 parotid-sparing protocols. The results reveal that spared PFR were not significantly higher 1 year post-RT in patients who had high pre-RT PFR, when compared with patients with low pre-RT PFR. However, patients who received higher doses of RT to spared parotid glands had lower PFR 1 year post-RT, compared with patients who had received lower doses of RT. These one-year findings suggest that high pre-RT PFR do not provide protection against RT-induced SGD. Conversely, reduced RT dosages to contralateral parotid glands are protective of PFR after completion of RT.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9680919</PMID><DateCompleted><Year>1998</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0275-1879</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>3</Issue><PubDate><MedlineDate>1998 May-Jun</MedlineDate></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers.</ArticleTitle><Pagination><MedlinePgn>102-8</MedlinePgn></Pagination><Abstract><AbstractText>Radiotherapy (RT) used for head and neck cancers causes permanent salivary gland dysfunction (SGD). Previous short-term studies have demonstrated that pre-RT salivary flow rates and the amount of radiation exposure to parotid glands influence the amount of RT-induced SGD. The purpose of this study was to determine which variables are related to the development of long-term post-RT SGD. Parotid flow rates (PFR) were assessed prior to and 1 year after completion of RT in spared parotid glands from 34 patients from 2 parotid-sparing protocols. The results reveal that spared PFR were not significantly higher 1 year post-RT in patients who had high pre-RT PFR, when compared with patients with low pre-RT PFR. However, patients who received higher doses of RT to spared parotid glands had lower PFR 1 year post-RT, compared with patients who had received lower doses of RT. These one-year findings suggest that high pre-RT PFR do not provide protection against RT-induced SGD. Conversely, reduced RT dosages to contralateral parotid glands are protective of PFR after completion of RT.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>D'Hondt</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Oral Medicine, Pathology, Surgery, University of Michigan School of Dentistry, Ann Arbor 48109-1078, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eisbruch</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ship</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DE07101</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Spec Care Dentist</MedlineTA><NlmUniqueID>8103755</NlmUniqueID><ISSNLinking>0275-1879</ISSNLinking></MedlineJournalInfo><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016371" MajorTopicYN="N">Cranial Irradiation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017742" MajorTopicYN="N">Dental Care for Chronically Ill</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004307" MajorTopicYN="N">Dose-Response Relationship, Radiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006258" MajorTopicYN="N">Head and Neck Neoplasms</DescriptorName><QualifierName UI="Q000532" MajorTopicYN="N">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010305" MajorTopicYN="N">Parotid Diseases</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010306" MajorTopicYN="N">Parotid Gland</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011829" MajorTopicYN="N">Radiation Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012466" MajorTopicYN="N">Salivary Gland Diseases</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012472" MajorTopicYN="N">Salivation</DescriptorName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012636" MajorTopicYN="N">Secretory Rate</DescriptorName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>7</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>7</Month><Day>29</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>7</Month><Day>29</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9680919</ArticleId><ArticleId IdType="doi">10.1111/j.1754-4505.1998.tb00913.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Eisbruch, A" sort="Eisbruch, A" uniqKey="Eisbruch A" first="A" last="Eisbruch">A. Eisbruch</name><name sortKey="Ship, J A" sort="Ship, J A" uniqKey="Ship J" first="J A" last="Ship">J A Ship</name></noCountry><country name="États-Unis"><noRegion><name sortKey="D Hondt, E" sort="D Hondt, E" uniqKey="D Hondt E" first="E" last="D'Hondt">E. D'Hondt</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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